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NeuroScience Associates

Hematoxylin and Eosin Stain (H&E)

In H&E stained sections, the term “red and dead” is an apt expression applied to the appearance of the cytoplasm in a cell that has just died, and “pink” if it is atrophic and near death. The positive sign for neurotoxicity for H&E is pink stained nucleoli against red stained neurons that represent normal healthy cells. If the dead cells are not coalesced and part of a massive lesion but instead comprise a dispersed population among normal appearing cells, detection is difficult since it requires microscopic examination at relatively high magnifications. SEE: Disintegrative Degeneration Stain for another option.

Hi magnification of affected case

Hi magnification of affected case

H&E on affected animal

H&E on affected animal

H&E on control case

H&E on control case

 

 

For further reference, please see: Stains

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