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NeuroScience Associates

Amyotrophic Lateral Sclerosis (ALS/Lou Gerhig’s Disease)

Overview

Also referred to as Lou Gerhig’s Disease, Amyotrophic Lateral Sclerosis (ALS) is a progressive, neurodegenerative disease affecting nerve cells in the brain and spinal cord. Motor neurons reach from the brain to the spinal cord, and from the spinal cord to the muscles throughout the body. The progressive degeneration of the motor neurons in ALS eventually leads to their death, resulting in a loss of the brain’s ability to initiate and control muscle movement.

ChAT Motor Neuron Marker

AMYOTROPHIC LATERAL Sclerosis (ALS)

Ubiquitin in SOD1 Mouse Model

AMYOTROPHIC LATERAL Sclerosis (ALS)

Amino Cupric Silver Stain

Amino Cupric Silver stain in SOD ALS mouse spinal cord model is shown below. The black “squiggles” are blood vessels and the fine black lines indicate bundles of degenerated axons.

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