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NeuroScience Associates

Chemistry or other Changes from Normal

NSA’s FDA Neurotoxicity Presentation 2015


In its most literal form, neurotoxicity could be defined as any departure from normal in the CNS. However, all departures from normal or changes in CNS are not negative. In fact, many compounds deliberately cause changes to the CNS as therapy. Judgment is required as to what changes constitute a negative impact and should be evaluated in the scope of a safety study. Most often, compounds that rely on a specific mechanism of action are evaluated with respect to their impact on the brain relative to that mechanism to make sure intended effects are not also accompanied by unintended ones. There are an incredible number of endpoints that could be evaluated to include a departure from normal. H&E is an example of one of the many tools used to evaluate general changes in the brain. Another common approach is to evaluate endpoints specific to the known mechanism of a compound to specifically quantify their impact on the brain. Examples of endpoints that are evaluated to reveal chemistry changes is the assessment of changes in neurotransmitter systems, as shown in the images below.





Learn more about NSA and NeuroSafety:

Neurosafety Overview Approach

Perturbations/Inflammation Evaluation

Permanent Damage Evaluation

Neonate/Juvenile Safety Studies Approach

NSA NeuroSafety Protocols


COVID-19 IMPACT: Our labs are currently OPEN for business. We are fully operational with uninterrupted delivery services ready to receive your tissue.


For clients with projects in process: NSA will communicate with you prior to shipping materials to ensure you are able to accept deliveries. If you are unable to receive deliveries due to the current global situation, NSA will hold shipments at our facility until your delivery system returns to normal. If you have not added digital imaging to your order but need it to expedite or continue your research, contact us right away so we can work together to meet your needs.

For clients with tissues, sections and/or slides located at our facility: Please allow us to help you continue your research, particularly if you are working remotely. We are able to perform additional stains, digitize slides for secure remote viewing, and perform additional analysis. Contact us today via email at or using our contact form.

For new clients: We are ready to assist you with all of your neurohistology needs. We are open and fully operational with uninterrupted delivery services ready to receive your tissue.. This is a dynamic situation and we will update this message as things change.

NSA strives to minimize the impact of this global situation on your research and the neuroscience community as a whole. We wish you and yours the best as we maneuver through uncharted waters. Please contact us if we can assist you in any way.